Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | BRS3 | P32247 | 2/20 | 0.41 |
| ▸ | WDR5 | P61964 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | ATP1A1 | P05023 | 2/20 | 0.40 |
| ▸ | ATP1B1 | P05026 | 2/20 | 0.40 |
| ▸ | ATP1A3 | P13637 | 2/20 | 0.40 |
| ▸ | ATP1B2 | P14415 | 2/20 | 0.40 |
| ▸ | ATP4A | P20648 | 2/20 | 0.40 |
| ▸ | ATP1A2 | P50993 | 2/20 | 0.40 |
| ▸ | ATP4B | P51164 | 2/20 | 0.40 |
| ▸ | ATP1B3 | P54709 | 2/20 | 0.40 |
| ▸ | FXYD2 | P54710 | 2/20 | 0.40 |
| ▸ | ATP1A4 | Q13733 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846721 | 0.93 | KMT2A (0.44) | KMT2AMEN1BRS3WDR5CYP2C9 | |
| SCHEMBL29474363 | 0.90 | KMT2A (0.43) | KMT2AMEN1BRS3WDR5CYP2C9 | |
| SCHEMBL7844981 | 0.89 | KMT2A (0.43) | KMT2AMEN1BRS3WDR5CYP2C9 | |
| SCHEMBL14344286 | 0.85 | KMT2A (0.45) | KMT2AMEN1BRS3WDR5CYP2C9 | |
| SCHEMBL21029237 | 0.85 | KMT2A (0.45) | KMT2AMEN1BRS3WDR5CYP2C9 | |
| SCHEMBL2592828 | 0.85 | KMT2A (0.45) | KMT2AMEN1BRS3WDR5CYP2C9 | |
| SCHEMBL3386628 | 0.85 | KMT2A (0.44) | KMT2AMEN1BRS3WDR5CYP2C9 | |
| SCHEMBL3386622 | 0.85 | KMT2A (0.44) | KMT2AMEN1BRS3WDR5CYP2C9 | |
| SCHEMBL18710710 | 0.85 | KMT2A (0.44) | KMT2AMEN1BRS3WDR5CYP2C9 | |
| SCHEMBL6772040 | 0.84 | KMT2A (0.41) | KMT2AMEN1BRS3WDR5CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105387-A1 | PRODRUGS OF PROTON PUMP INHIBITORS | Partnership of Michael E. Garst, George Sachs and Jai Moo Shin (US) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000009498-A1 | PRODRUGS OF PROTON PUMP INHIBITORS | PARTNERSHIP OF MICHAEL E. GARST, GEORGE SACHS AND JAI MOO SHIN (US) | 2000-02-24 | — | — | WO | disclosed |