Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.64 |
| ▸ | PDE4A | P27815 | 11/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.64 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.64 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7850689 | 1.00 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7849579 | 0.89 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7843451 | 0.88 | PDE4B (0.79) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7851425 | 0.88 | PDE4B (0.79) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7850728 | 0.86 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7852689 | 0.86 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7855356 | 0.85 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7851746 | 0.85 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7855075 | 0.80 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL7850746 | 0.80 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730579-B1 | SUBSTITUTED INDOLES AS PHOSPHODIESTERASE TYPE IV INHIBITORS | PFIZER (US) | 2001-03-07 | — | — | EP | claimed |
| EP-0730579-B1 | SUBSTITUTED INDOLES AS PHOSPHODIESTERASE TYPE IV INHIBITORS | PFIZER (US) | 2001-03-07 | — | — | EP | disclosed |