Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.69 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7853662 | 0.83 | PTPN1 (0.67) | PTPN1PTPN2ADORA1KDM4EMEN1 | |
| SCHEMBL7847188 | 0.82 | PTPN1 (0.65) | PTPN1PTPN2ADORA1KDM4EMEN1 | |
| SCHEMBL7859688 | 0.81 | PTPN1 (0.65) | PTPN1PTPN2ADORA1KDM4EALDH1A1 | |
| SCHEMBL6323368 | 0.81 | PTPN1 (1.00) | PTPN1PTPN2 | |
| SCHEMBL7160346 | 0.79 | PTPN1 (0.67) | PTPN1PTPN2ADORA1KDM4ELMNA | |
| SCHEMBL7852313 | 0.77 | PTPN1 (0.68) | PTPN1PTPN2ADORA1KDM4EMEN1 | |
| SCHEMBL7154838 | 0.77 | PTPN1 (0.48) | PTPN1PTPN2KDM4ELMNAALDH1A1 | |
| SCHEMBL7170012 | 0.76 | KMT2A (0.49) | PTPN1PTPN2LMNAALDH1A1MEN1 | |
| SCHEMBL7855098 | 0.75 | PTPN2 (0.58) | PTPN1PTPN2ADORA1KDM4EALDH1A1 | |
| SCHEMBL7855558 | 0.73 | KMT2A (0.53) | PTPN1PTPN2ADORA1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080068-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES | Novo Nordisk A/S (DK) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999046237-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |