Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 13/20 | 0.70 |
| ▸ | EGFR | P00533 | 9/20 | 0.70 |
| ▸ | ABL1 | P00519 | 7/20 | 0.70 |
| ▸ | ABL2 | P42684 | 7/20 | 0.70 |
| ▸ | CDK1 | P06493 | 6/20 | 0.70 |
| ▸ | KDR | P35968 | 5/20 | 0.70 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.57 |
| ▸ | CSK | P41240 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842356 | 0.93 | SRC (0.82) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL2800044 | 0.84 | SRC (0.60) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL31061695 | 0.82 | SRC (1.00) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL5936176 | 0.82 | SRC (1.00) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL20351594 | 0.82 | SRC (0.86) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL30582589 | 0.81 | AXL (0.63) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL26110170 | 0.81 | AXL (0.63) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7845787 | 0.81 | SRC (0.84) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7845704 | 0.81 | SRC (0.84) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7847666 | 0.81 | SRC (0.62) | SRCEGFRABL1ABL2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783505-B1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| EP-0783505-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | Novartis AG (CH) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010028-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 1996-04-04 | — | — | WO | disclosed |