SCHEMBL7843890

SCHEMBL7843890

O=C(NC1CCCCC1)C(O)C1CCCN1C(=O)C=Cc1ccc(Cl)cc1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.51
CYP3A4 P08684 1/20 0.45
HTT P42858 1/20 0.42
TSHR P16473 1/20 0.42
CYP1A2 P05177 2/20 0.42
CYP2C19 P33261 3/20 0.41
USP2 O75604 1/20 0.41
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
GAA P10253 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
ALDH1A1 P00352 3/20 0.40
MAPT P10636 1/20 0.40
HPGD P15428 1/20 0.40
POLB P06746 1/20 0.39
EPHX1 P07099 1/20 0.39
CYP2C9 P11712 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7852885 0.89 CYP3A4 (0.57) HRH3CYP3A4TSHRCYP1A2CYP2C19
SCHEMBL7853401 0.82 C3AR1 (0.60) CYP3A4CYP2C19USP2NPC1RAB9A
SCHEMBL7856400 0.79 HRH3 (0.53) HRH3CYP3A4HTTTSHRCYP1A2
SCHEMBL9652218 0.71 HRH3 (0.62) HRH3HTTTSHRCYP1A2NPC1
SCHEMBL9652226 0.71 HRH3 (0.62) HRH3HTTTSHRCYP1A2NPC1
SCHEMBL7852710 0.70 KMT2A (0.42) CYP3A4TSHRCYP2C19NPC1RAB9A
SCHEMBL5958400 0.69 HRH3 (0.98) HRH3CYP3A4HTTCYP1A2CYP2C19
SCHEMBL14409493 0.69 HRH3 (0.98) HRH3CYP3A4HTTCYP1A2CYP2C19
SCHEMBL7852978 0.69 SMN1; SMN2 (0.50) HRH3CYP2C19NPC1RAB9AL3MBTL1
SCHEMBL7854808 0.68 EPHX2 (0.57) CYP3A4TSHRCYP2C19GAAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0709373-B1 PYRROLIDINE DERIVATIVE ZAIDAN HOJIN BISEIBUTSU (JP) 2001-10-17 EP disclosed
US-5965556-A KETO-ACID AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS FOR INHIBITING THE ACTIVITY OF SERINE PROTEASE OR THIOL PROTEASE BY ADMINISTERING THE DERIVATIVE TO A MAMMAL; ALZHEIMER'S DISEASE ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) 1999-10-12 US disclosed
US-5756763-A ENZYME INHIBITOR ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) 1998-05-26 US disclosed
EP-0709373-A1 NOVEL PYRROLIDINE DERIVATIVE ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) 1996-05-01 EP disclosed