Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.59 |
| ▸ | F2 | P00734 | 1/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.55 |
| ▸ | CMA1 | P23946 | 15/20 | 0.54 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CTRC | Q99895 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852721 | 0.88 | ACE (0.58) | ACEKMT2A | |
| SCHEMBL7855038 | 0.87 | KDM4E (0.58) | ACE | |
| SCHEMBL8378100 | 0.86 | ACE (0.77) | ACEF2PRSS1CMA1KLK5 | |
| SCHEMBL22409423 | 0.86 | ACE (0.77) | ACEF2PRSS1CMA1KLK5 | |
| SCHEMBL5900839 | 0.86 | ACE (0.77) | ACEF2PRSS1CMA1KLK5 | |
| SCHEMBL3692085 | 0.86 | ACE (0.77) | ACEF2PRSS1CMA1KLK5 | |
| SCHEMBL5900836 | 0.86 | ACE (0.77) | ACEF2PRSS1CMA1KLK5 | |
| SCHEMBL3692081 | 0.86 | ACE (0.77) | ACEF2PRSS1CMA1KLK5 | |
| SCHEMBL7845289 | 0.85 | ACE (0.59) | ACE | |
| SCHEMBL6412055 | 0.84 | ACE (0.66) | ACEF2PRSS1CMA1KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709373-B1 | PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU (JP) | 2001-10-17 | — | — | EP | disclosed |
| US-5965556-A | KETO-ACID AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS FOR INHIBITING THE ACTIVITY OF SERINE PROTEASE OR THIOL PROTEASE BY ADMINISTERING THE DERIVATIVE TO A MAMMAL; ALZHEIMER'S DISEASE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1999-10-12 | — | — | US | disclosed |
| US-5756763-A | ENZYME INHIBITOR | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1998-05-26 | — | — | US | disclosed |
| EP-0709373-A1 | NOVEL PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1996-05-01 | — | — | EP | disclosed |