Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AS3MT | Q9HBK9 | 3/20 | 0.55 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | ABL2 | P42684 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7833944 | 0.89 | AS3MT (0.49) | AS3MTMAOBNSD2GRM5PDCD1 | |
| SCHEMBL7836453 | 0.87 | AS3MT (0.42) | AS3MTABL1EGFRCDK1SRC | |
| SCHEMBL1907296 | 0.81 | SRC (0.45) | AS3MTABL1EGFRCDK1SRC | |
| SCHEMBL7835925 | 0.80 | CA12 (0.54) | ABL1EGFRCDK1SRCABL2 | |
| SCHEMBL7847918 | 0.78 | SRC (0.55) | PDCD1CD274ABL1EGFRCDK1 | |
| SCHEMBL14673720 | 0.77 | CA12 (0.48) | AS3MTABL1EGFRCDK1SRC | |
| SCHEMBL27322830 | 0.75 | AS3MT (0.39) | AS3MTNSD2PDCD1CD274PIM1 | |
| SCHEMBL7835893 | 0.74 | KDM4E (0.50) | SRC | |
| SCHEMBL7845816 | 0.74 | SRC (0.76) | ABL1EGFRCDK1SRCABL2 | |
| SCHEMBL1902613 | 0.74 | CA12 (0.56) | PIM1ABL1EGFRCDK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783505-B1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| CN-1046731-C | Pyrrolo [2,3-d ] pyrimidines and their use | NOVARTIS AG (CH) | 1999-11-24 | — | — | CN | disclosed |
| US-5869485-A | Pyrrolo 2,3-d!pyrimidines and their use | NOVARTIS FINANCE CORP. (US) | 1999-02-09 | — | — | US | disclosed |
| CN-1164234-A | Pyrrolo [2, 3-d ] pyrimidines and their use | NOVARTIS AG (CH) | 1997-11-05 | — | — | CN | disclosed |
| EP-0783505-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | Novartis AG (CH) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010028-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 1996-04-04 | — | — | WO | disclosed |