Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 12/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.44 |
| ▸ | BUB1 | O43683 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14411681 | 0.86 | MAPK11 (0.60) | MAPK11MAPK14KCNH2 | |
| SCHEMBL5256058 | 0.86 | MAPK11 (0.60) | MAPK11MAPK14KCNH2 | |
| SCHEMBL14411923 | 0.74 | MAPK11 (0.58) | MAPK11MAPK14KCNH2 | |
| SCHEMBL5259074 | 0.73 | MAPK11 (0.70) | MAPK11MAPK14KCNH2 | |
| SCHEMBL5257782 | 0.73 | MAPK11 (0.70) | MAPK11MAPK14KCNH2 | |
| SCHEMBL14521933 | 0.72 | MAPK11 (0.47) | MAPK11MAPK14BUB1DRD2DRD3 | |
| SCHEMBL5258912 | 0.71 | MAPK11 (0.69) | MAPK11MAPK14KCNH2 | |
| SCHEMBL5256172 | 0.67 | MAPK11 (0.70) | MAPK11MAPK14KCNH2 | |
| SCHEMBL5454667 | 0.66 | LRRK2 (0.50) | MAPK11MAPK14CNR1CNR2 | |
| SCHEMBL19380852 | 0.66 | KDM1A (0.68) | BTKDRD2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144403-A1 | SUBSTITUED PYRAZOLES AS P38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000031063-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-06-02 | — | — | WO | disclosed |