Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.82 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.82 |
| ▸ | HCK | P08631 | 11/20 | 0.82 |
| ▸ | TNF | P01375 | 2/20 | 0.82 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6892709 | 0.92 | MAPK14 (0.69) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL29593358 | 0.90 | MAPK14 (1.00) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL295686 | 0.90 | MAPK14 (1.00) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL29593430 | 0.88 | MAPK14 (0.85) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL296491 | 0.88 | MAPK14 (0.85) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL13481445 | 0.87 | MAPK14 (0.88) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL295612 | 0.86 | MAPK14 (0.92) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL29594379 | 0.86 | MAPK14 (0.92) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL28471634 | 0.86 | MAPK14 (0.80) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL6243534 | 0.85 | MAPK14 (0.83) | MAPK14MAPK12HCKTNFSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147104-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043384-A1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-07-27 | — | — | WO | claimed |