SCHEMBL7845240

SCHEMBL7845240

COc1cc2c(cc1OC)C(c1ccc(CNC3CCC3)cc1)N(CCCC(CCCNC(=O)CCc1ccc(F)cc1)(c1ccccc1)c1ccccc1)CC2

nearest known ligand 0.42

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 8/20 0.42
HCRTR2 O43614 5/20 0.42
TRPV1 Q8NER1 1/20 0.41
ACHE P22303 4/20 0.39
LMNA P02545 2/20 0.38
NPC1 O15118 1/20 0.38
MITF O75030 1/20 0.38
ALDH1A1 P00352 1/20 0.38
XBP1 P17861 1/20 0.38
HTT P42858 1/20 0.38
RAB9A P51151 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
TP53 P04637 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7843467 0.92 HCRTR1 (0.47) HCRTR1HCRTR2TRPV1ACHELMNA
SCHEMBL7852667 0.90 HCRTR1 (0.44) HCRTR1HCRTR2TRPV1ACHELMNA
Hydrochloric Acid SCHEMBL7855751 0.90 HCRTR1 (0.44) HCRTR1HCRTR2TRPV1ACHELMNA
Hydrochloric Acid SCHEMBL7855468 0.90 HCRTR1 (0.44) HCRTR1HCRTR2TRPV1ACHELMNA
Hydrochloric Acid SCHEMBL7843496 0.90 HCRTR1 (0.44) HCRTR1HCRTR2TRPV1ACHELMNA
Hydrochloric Acid SCHEMBL7848773 0.89 HCRTR1 (0.42) HCRTR1HCRTR2TRPV1ACHELMNA
Hydrochloric Acid SCHEMBL7852742 0.87 HCRTR1 (0.45) HCRTR1HCRTR2ACHELMNATP53
Hydrochloric Acid SCHEMBL7847363 0.86 HCRTR1 (0.46) HCRTR1HCRTR2ACHELMNATP53
SCHEMBL7853411 0.85 HCRTR1 (0.50) HCRTR1HCRTR2LMNATP53
Hydrochloric Acid SCHEMBL7848616 0.85 HCRTR1 (0.46) HCRTR1HCRTR2ACHELMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1129076-A1 TETRAHYDROISOQUINOLINE DERIVATIVES AS LHRH ANTAGONISTS ABBOTT LABORATORIES (US) 2001-09-05 EP disclosed
WO-2000029380-A1 TETRAHYDROISOQUINOLINE DERIVATIVES AS LHRH ANTAGONISTS ABBOTT LABORATORIES (US) 2000-05-25 WO disclosed
US-5981521-A USEFUL FOR TREATING VARIOUS HORMONE DEPENDENT DISEASES, INCLUDING PROSTATE CANCER, ENDOMETRIOSIS, UTERINE FIBROIDS, PRECOCIOUS PUBERTY, BENIGN PROSTATE HYPERTROPY AND IN VITRO FERTILIZATION ABBOTT LABORATORIES (US) 1999-11-09 US disclosed