Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 14/20 | 0.55 |
| ▸ | HTR1B | P28222 | 14/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | HTR1F | P30939 | 3/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6640192 | 0.92 | HTR1D (0.63) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3337136 | 0.83 | APP (0.57) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8820381 | 0.80 | HTR1D (0.47) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9836165 | 0.79 | KDM4E (0.63) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17060365 | 0.79 | HSP90AA1 (0.54) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15712312 | 0.78 | HSP90AA1 (0.56) | MAPTSLC6A4 | |
| SCHEMBL5369303 | 0.77 | HTR1D (0.50) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9836911 | 0.77 | HTR2C (0.55) | APPSLC6A4 | |
| SCHEMBL7489905 | 0.76 | HTR1D (0.76) | HTR1DHTR1BHTR1AHTR1F | |
| Phosphoric Acid SCHEMBL7867279 | 0.76 | CYP1A2 (0.46) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089993-A1 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000487-A1 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2000-01-06 | — | — | WO | disclosed |