SCHEMBL7846568

SCHEMBL7846568

Nc1ccc2c(c1)OC1(CCNCC1)CC2=O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 9/20 0.57
HDAC4 P56524 9/20 0.57
HDAC1 Q13547 9/20 0.57
HDAC7 Q8WUI4 9/20 0.57
HDAC2 Q92769 9/20 0.57
HDAC10 Q969S8 9/20 0.57
HDAC11 Q96DB2 9/20 0.57
HDAC8 Q9BY41 9/20 0.57
HDAC6 Q9UBN7 9/20 0.57
HDAC9 Q9UKV0 9/20 0.57
HDAC5 Q9UQL6 9/20 0.57
KDM4E B2RXH2 3/20 0.43
ATM Q13315 3/20 0.42
HTT P42858 1/20 0.42
ALDH1A1 P00352 1/20 0.38
SIGMAR1 Q99720 1/20 0.38
CA1 P00915 2/20 0.36
CA2 P00918 2/20 0.36
CA7 P43166 2/20 0.36
CA9 Q16790 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12658013 0.89 HDAC3 (0.57) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL11112095 0.85 KDM4E (0.57) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL13791454 0.83 HDAC3 (0.60) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL537621 0.83 HDAC3 (0.57) HDAC3HDAC4HDAC1HDAC7HDAC2
Hydrochloric Acid SCHEMBL537822 0.82 HDAC8 (0.56) HDAC3HDAC4HDAC1HDAC7HDAC2
Hydrochloric Acid SCHEMBL4265245 0.81 HDAC8 (0.55) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL4389032 0.81 HDAC3 (0.55) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL4508454 0.80 KDM4E (0.55) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL18148497 0.80 HDAC3 (0.60) HDAC3HDAC4HDAC1HDAC7HDAC2
Hydrochloric Acid SCHEMBL3493596 0.80 HDAC3 (0.54) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2123652-A1 HETEROCYCLIC COMPOUND Takeda Pharmaceutical Company Limited (JP) 2009-11-25 EP disclosed
EP-0831824-A4 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO INC (US) 2001-05-02 EP disclosed
EP-0831824-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 1998-04-01 EP disclosed
WO-1996039140-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1996-12-12 WO disclosed