SCHEMBL7846678

SCHEMBL7846678

Nc1c(O)ccc2ncccc12

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 5/20 0.66
LMNA P02545 4/20 0.66
MAPT P10636 3/20 0.66
HSP90AB1 P08238 3/20 0.66
MEN1 O00255 3/20 0.66
KMT2A Q03164 3/20 0.66
HTT P42858 3/20 0.66
BLM P54132 2/20 0.66
HIF1A Q16665 1/20 0.66
KDM4E B2RXH2 7/20 0.58
ERN1 O75460 1/20 0.56
IDO1 P14902 2/20 0.52
PSMB5 P28074 1/20 0.52
RAB9A P51151 3/20 0.47
L3MBTL1 Q9Y468 3/20 0.47
NPC1 O15118 2/20 0.47
NPSR1 Q6W5P4 1/20 0.47
CYP3A4 P08684 1/20 0.47
IL1B P01584 1/20 0.44
NCF1 P14598 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30028810 0.79 KDM4E (0.62) HSP90AA1LMNAMAPTHSP90AB1MEN1
SCHEMBL21075158 0.79 KDM4E (0.62) HSP90AA1LMNAMAPTHSP90AB1MEN1
SCHEMBL3155534 0.79 KDM4E (0.62) HSP90AA1LMNAMAPTHSP90AB1MEN1
SCHEMBL1085388 0.79 MAPT (1.00) HSP90AA1LMNAMAPTHSP90AB1MEN1
SCHEMBL29661896 0.79 MAPT (1.00) HSP90AA1LMNAMAPTHSP90AB1MEN1
Hydrochloric Acid SCHEMBL2645961 0.78 MAPT (0.96) HSP90AA1LMNAMAPTHSP90AB1MEN1
Hydrochloric Acid SCHEMBL30075709 0.78 MAPT (0.96) HSP90AA1LMNAMAPTHSP90AB1MEN1
SCHEMBL14242728 0.76 KDM4E (0.58) HSP90AA1LMNAMAPTHSP90AB1MEN1
SCHEMBL3896832 0.76 KDM4E (0.58) HSP90AA1LMNAMAPTHSP90AB1MEN1
SCHEMBL5020270 0.76 KDM4E (0.58) HSP90AA1LMNAMAPTHSP90AB1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0656893-B1 PHOTOCHROMIC OXAZINE COMPOUNDS RODENSTOCK OPTIK G (DE) 2001-12-12 EP claimed
US-5801243-A REACTING A SUBSTITUTED ALDEHYDE WITH A SUBSTITUTED ORTHO-AMINO-HYDROXY AROMATIC COMPOUND OPTISCHE WERKE G. RODENSTOCK (DE) 1998-09-01 US claimed
EP-0656893-A1 PHOTOCHROMIC OXAZINE COMPOUNDS Optische Werke G. Rodenstock (DE) 1995-06-14 EP claimed
WO-1995000500-A1 PHOTOCHROMIC OXAZINE COMPOUNDS OPTISCHE WERKE G. RODENSTOCK (DE) 1995-01-05 WO claimed
EP-0656893-B1 PHOTOCHROMIC OXAZINE COMPOUNDS RODENSTOCK OPTIK G (DE) 2001-12-12 EP disclosed
EP-0656893-A1 PHOTOCHROMIC OXAZINE COMPOUNDS Optische Werke G. Rodenstock (DE) 1995-06-14 EP disclosed
WO-1995000500-A1 PHOTOCHROMIC OXAZINE COMPOUNDS OPTISCHE WERKE G. RODENSTOCK (DE) 1995-01-05 WO disclosed