SCHEMBL7846802

SCHEMBL7846802

CCCCCCCCCCSc1ccc(C#N)cc1SCCCCCCCCCC

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.44
HSD17B10 Q99714 2/20 0.44
KDM4E B2RXH2 4/20 0.40
ALDH1A1 P00352 4/20 0.40
HPGD P15428 2/20 0.40
HTT P42858 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
CYP1A2 P05177 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
GAA P10253 1/20 0.40
PTGS2 P35354 3/20 0.38
AR P10275 2/20 0.38
DRD2 P14416 2/20 0.37
DRD3 P35462 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7581913 0.80 MEN1 (0.43) TSHRHSD17B10KDM4EALDH1A1HPGD
SCHEMBL7573896 0.80 MEN1 (0.43) TSHRHSD17B10KDM4EALDH1A1HPGD
SCHEMBL7575760 0.80 MEN1 (0.43) TSHRHSD17B10KDM4EALDH1A1HPGD
SCHEMBL7574846 0.80 MEN1 (0.43) TSHRHSD17B10KDM4EALDH1A1HPGD
SCHEMBL7580258 0.80 MEN1 (0.43) TSHRHSD17B10KDM4EALDH1A1HPGD
SCHEMBL7582752 0.80 MEN1 (0.43) TSHRHSD17B10KDM4EALDH1A1HPGD
SCHEMBL7575513 0.80 MEN1 (0.43) TSHRHSD17B10KDM4EALDH1A1HPGD
SCHEMBL8569987 0.80 TSHR (0.50) TSHRHSD17B10KDM4EALDH1A1HPGD
SCHEMBL8565067 0.80 TSHR (0.50) TSHRHSD17B10KDM4EALDH1A1HPGD
SCHEMBL2552925 0.80 TSHR (0.50) TSHRHSD17B10KDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0944632-B1 LIQUID CRYSTALLINE DIKETOPYRROLOPYRROLES CIBA SC HOLDING AG (CH) 2001-02-14 EP disclosed
US-5969154-A COLORED LIQUID CRYSTALLINE PHASES CIBA SPECIALTY CHEMICALS CORPORATION (US) 1999-10-19 US disclosed
EP-0944632-A1 LIQUID CRYSTALLINE DIKETOPYRROLOPYRROLES Ciba SC Holding AG (CH) 1999-09-29 EP disclosed
US-5866594-A Indole-2-carboxylate derivatives and fungicidal compositions for agricultural or horticultural use containing the derivatives as active component OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1999-02-02 US disclosed
WO-1998025927-A1 LIQUID CRYSTALLINE DIKETOPYRROLOPYRROLES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 1998-06-18 WO disclosed
EP-0791582-A1 INDOLE-2-CARBOXYLIC ESTER DERIVATIVES AND AGRICULTURAL AND HORTICULTURAL BACTERIOCIDES CONTAINING THE SAME AS THE ACTIVE INGREDIENT OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1997-08-27 EP disclosed