Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 18/20 | 0.71 |
| ▸ | EGFR | P00533 | 12/20 | 0.71 |
| ▸ | ABL1 | P00519 | 9/20 | 0.71 |
| ▸ | ABL2 | P42684 | 9/20 | 0.71 |
| ▸ | CDK1 | P06493 | 7/20 | 0.71 |
| ▸ | KDR | P35968 | 6/20 | 0.71 |
| ▸ | CSK | P41240 | 2/20 | 0.59 |
| ▸ | BTK | Q06187 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7845723 | 0.87 | SRC (0.76) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL5936176 | 0.84 | SRC (1.00) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL31061695 | 0.84 | SRC (1.00) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7843715 | 0.83 | SRC (0.78) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7833854 | 0.82 | SRC (0.86) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7843386 | 0.81 | SRC (1.00) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7835166 | 0.80 | SRC (0.81) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7844144 | 0.80 | SRC (0.78) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL20911824 | 0.80 | SRC (0.71) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7841486 | 0.79 | SRC (0.78) | SRCEGFRABL1ABL2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783505-B1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| EP-0783505-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | Novartis AG (CH) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010028-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 1996-04-04 | — | — | WO | disclosed |