Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 18/20 | 0.66 |
| ▸ | DHFR | P00374 | 2/20 | 0.60 |
| ▸ | FOLR1 | P15328 | 2/20 | 0.60 |
| ▸ | SLC19A1 | P41440 | 2/20 | 0.60 |
| ▸ | SLC46A1 | Q96NT5 | 2/20 | 0.60 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.60 |
| ▸ | GART | P22102 | 1/20 | 0.60 |
| ▸ | ATIC | P31939 | 1/20 | 0.60 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.60 |
| ▸ | FRK | P42685 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2260428 | 0.93 | TYMS (0.69) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL2260030 | 0.92 | TYMS (0.67) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL17518729 | 0.85 | TYMS (0.62) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL18551642 | 0.84 | TYMS (0.64) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL13659935 | 0.83 | TYMS (0.63) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL7836050 | 0.82 | GART (0.90) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL20780521 | 0.82 | TYMS (0.56) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL2260032 | 0.82 | TYMS (0.68) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL28417050 | 0.82 | TYMS (0.45) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL7836419 | 0.81 | NAMPT (0.56) | TYMSDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112442038-B | Industrial preparation method of pemetrexed disodium | 德州德药制药有限公司 | 2022-09-02 | — | — | CN | claimed |
| CN-112174970-B | Method for preparing pemetrexed disodium with high yield | 德州德药制药有限公司 | 2022-06-07 | — | — | CN | claimed |
| CN-112442038-A | Industrial preparation method of pemetrexed disodium | 德州德药制药有限公司 | 2021-03-05 | — | — | CN | claimed |
| CN-112174970-A | Method for preparing pemetrexed disodium in high yield | 德州德药制药有限公司 | 2021-01-05 | — | — | CN | claimed |
| CN-112442038-B | Industrial preparation method of pemetrexed disodium | 德州德药制药有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-112174970-B | Method for preparing pemetrexed disodium with high yield | 德州德药制药有限公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-112442038-A | Industrial preparation method of pemetrexed disodium | 德州德药制药有限公司 | 2021-03-05 | — | — | CN | disclosed |
| CN-112174970-A | Method for preparing pemetrexed disodium in high yield | 德州德药制药有限公司 | 2021-01-05 | — | — | CN | disclosed |
| EP-1105396-A1 | PROCESS FOR THE PREPARATION OF PYRROLO[2,3-D]PYRIMIDINES | The Trustees of Princeton University (US) | 2001-06-13 | — | — | EP | disclosed |
| US-6066732-A | Process for the preparation of pyrrolo[2,3-d]pyrimidines | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2000-05-23 | — | — | US | disclosed |
| WO-2000011004-A1 | PROCESS FOR THE PREPARATION OF PYRROLO[2,3-D]PYRIMIDINES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2000-03-02 | — | — | WO | disclosed |