Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 16/20 | 0.73 |
| ▸ | EGFR | P00533 | 10/20 | 0.73 |
| ▸ | ABL1 | P00519 | 9/20 | 0.73 |
| ▸ | ABL2 | P42684 | 9/20 | 0.73 |
| ▸ | CDK1 | P06493 | 6/20 | 0.73 |
| ▸ | KDR | P35968 | 5/20 | 0.73 |
| ▸ | CSK | P41240 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.56 |
| ▸ | PRKDC | P78527 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7833880 | 0.95 | SRC (0.75) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7835124 | 0.91 | SRC (0.62) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7845816 | 0.89 | SRC (0.76) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7844800 | 0.88 | SRC (0.73) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7844861 | 0.88 | SRC (0.73) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7848781 | 0.87 | SRC (0.71) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7844053 | 0.86 | SRC (0.70) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7845043 | 0.86 | SRC (0.70) | SRCEGFRABL1ABL2CDK1 | |
| SCHEMBL7844437 | 0.86 | SRC (0.62) | SRCEGFRABL1ABL2CDK1 | |
| Dimethylamine SCHEMBL7844070 | 0.86 | SRC (0.64) | SRCEGFRABL1ABL2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783505-B1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| EP-0783505-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | Novartis AG (CH) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010028-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 1996-04-04 | — | — | WO | disclosed |