Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 19/20 | 0.61 |
| ▸ | TACR2 | P21452 | 3/20 | 0.61 |
| ▸ | TACR3 | P29371 | 3/20 | 0.61 |
| ▸ | CCR5 | P51681 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296291 | 0.94 | TACR1 (0.63) | TACR1TACR2TACR3 | |
| SCHEMBL8292835 | 0.91 | TACR1 (0.56) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL8483783 | 0.89 | TACR1 (0.50) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL4631309 | 0.84 | TACR1 (0.45) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL8203185 | 0.83 | TACR1 (0.68) | TACR1TACR2TACR3CCR5 | |
| SCHEMBL8479705 | 0.83 | TACR1 (0.51) | TACR1TACR2TACR3 | |
| SCHEMBL8366723 | 0.82 | TACR1 (0.49) | TACR1TACR2TACR3 | |
| SCHEMBL8563879 | 0.82 | TACR1 (0.49) | TACR1TACR2TACR3 | |
| SCHEMBL4662770 | 0.81 | TACR1 (0.43) | TACR1TACR2TACR3 | |
| SCHEMBL4631694 | 0.79 | TACR1 (0.46) | TACR1TACR2TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003743-A4 | 3,3-DISUBSTITUTED PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2001-04-11 | — | — | EP | disclosed |
| US-6124319-A | TREATING INFLAMMATORY AND IMMUNOREGULATORY DISORDERS AND DISEASES, INCLUDING ASTHMA AND ALLERGIC DISEASES, AUTOIMMUNE PATHOLOGIES SUCH AS RHEUMATOID ARTHRITIS AND ATHEROSCLEROSIS | MERCK & CO., INC. (US) | 2000-09-26 | — | — | US | disclosed |
| EP-1003743-A1 | 3,3-DISUBSTITUTED PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1998031364-A1 | 3,3-DISUBSTITUTED PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 1998-07-23 | — | — | WO | disclosed |