Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 15/20 | 1.00 |
| ▸ | EGFR | P00533 | 10/20 | 1.00 |
| ▸ | ABL1 | P00519 | 8/20 | 1.00 |
| ▸ | ABL2 | P42684 | 8/20 | 1.00 |
| ▸ | KDR | P35968 | 6/20 | 1.00 |
| ▸ | CDK1 | P06493 | 6/20 | 0.77 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | TEK | Q02763 | 1/20 | 0.60 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844216 | 0.89 | SRC (0.83) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL7848082 | 0.89 | SRC (0.80) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL15934520 | 0.89 | SRC (0.80) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL7834901 | 0.87 | SRC (1.00) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL31061695 | 0.87 | SRC (1.00) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL5936176 | 0.87 | SRC (1.00) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL20351594 | 0.86 | SRC (0.86) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL7833880 | 0.86 | SRC (0.75) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL20912242 | 0.85 | SRC (0.76) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL7842849 | 0.85 | SRC (0.73) | SRCEGFRABL1ABL2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783505-B1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2001-03-07 | — | — | EP | disclosed |
| EP-0783505-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | Novartis AG (CH) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996010028-A1 | PYRROLO[2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 1996-04-04 | — | — | WO | disclosed |