Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 9/20 | 0.61 |
| ▸ | FNTA | P49354 | 8/20 | 0.60 |
| ▸ | FNTB | P49356 | 8/20 | 0.60 |
| ▸ | PGGT1B | P53609 | 6/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.59 |
| ▸ | NRAS | P01111 | 1/20 | 0.52 |
| ▸ | HRAS | P01112 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842322 | 0.91 | FNTA (0.49) | OPRL1FNTAFNTBPGGT1BOPRM1 | |
| SCHEMBL7839252 | 0.90 | FNTA (0.54) | OPRL1FNTAFNTBPGGT1BOPRM1 | |
| SCHEMBL16718977 | 0.84 | OPRL1 (0.53) | OPRL1OPRM1OPRD1OPRK1DRD4 | |
| SCHEMBL16718978 | 0.84 | OPRL1 (0.53) | OPRL1OPRM1OPRD1OPRK1DRD4 | |
| SCHEMBL7844152 | 0.78 | FNTA (0.56) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL7840456 | 0.78 | FNTA (0.56) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL7847623 | 0.76 | OPRL1 (1.00) | OPRL1OPRM1OPRD1OPRK1DRD4 | |
| SCHEMBL7831091 | 0.76 | FNTA (0.60) | FNTAFNTBPGGT1BNRASHRAS | |
| Hydrochloric Acid SCHEMBL7991896 | 0.76 | FNTA (0.59) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL7842924 | 0.75 | FNTA (0.60) | FNTAFNTBPGGT1BNRASHRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172076-B1 | HETEROCYCLE-SUBSTITUTED 1,3,8-TRIAZASPIRO(4,5)DECANE DERIVATIVES; TREATING ARTERIOSCLEROSIS | MERCK & CO., INC. | 2001-01-09 | — | — | US | claimed |
| EP-1087770-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-1087770-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| US-6172076-B1 | HETEROCYCLE-SUBSTITUTED 1,3,8-TRIAZASPIRO(4,5)DECANE DERIVATIVES; TREATING ARTERIOSCLEROSIS | MERCK & CO., INC. | 2001-01-09 | — | — | US | disclosed |
| WO-1999065494-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-12-23 | — | — | WO | disclosed |