Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 10/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | LYN | P07948 | 2/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897191 | 0.91 | CSF1R (0.74) | CSF1RALDH1A1GAAMAPTBRAF | |
| SCHEMBL7850678 | 0.89 | MAPT (0.60) | CSF1RALDH1A1GAAMAPTMAPK14 | |
| SCHEMBL5897317 | 0.82 | MAPK14 (0.66) | CSF1RMAPTBRAFMAPK14TDP1 | |
| SCHEMBL2975514 | 0.79 | MAPT (0.64) | CSF1RALDH1A1GAAMAPTBRAF | |
| SCHEMBL4878747 | 0.78 | CSF1R (0.52) | CSF1RALDH1A1MAPTBRAFMAPK14 | |
| SCHEMBL7827478 | 0.78 | CSF1R (0.52) | CSF1RMAPTBRAFMAPK14LYN | |
| SCHEMBL7851337 | 0.77 | MAPK14 (0.52) | MAPTBRAFMAPK14 | |
| SCHEMBL5897092 | 0.76 | MAPK14 (0.71) | MAPTBRAFMAPK14TDP1RAF1 | |
| SCHEMBL7822467 | 0.76 | BRAF (0.54) | CSF1RBRAFMAPK14LYNKIT | |
| SCHEMBL25238622 | 0.76 | CSF1R (1.00) | CSF1RBRAFMAPK14LYNKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102750-A1 | AMIDE DERIVATIVES USEFUL AS INHIBITORS OF THE PRODUCTION OF CYTOKINES | AstraZeneca AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007991-A1 | AMIDE DERIVATIVES USEFUL AS INHIBITORS OF THE PRODUCTION OF CYTOKINES | ASTRAZENECA AB (SE) | 2000-02-17 | — | — | WO | disclosed |