Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 18/20 | 0.64 |
| ▸ | GAK | O14976 | 1/20 | 0.57 |
| ▸ | STK4 | Q13043 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7849209 | 0.85 | EGFR (0.55) | EGFRERBB2GAK | |
| SCHEMBL6507325 | 0.84 | EGFR (0.81) | EGFRERBB2GAKSTK4 | |
| SCHEMBL7847647 | 0.83 | EGFR (0.63) | EGFRERBB2GAKSTK4 | |
| SCHEMBL1418349 | 0.82 | EGFR (0.65) | EGFRERBB2GAKSTK4 | |
| SCHEMBL7849869 | 0.82 | EGFR (0.61) | EGFRERBB2GAKSTK4 | |
| SCHEMBL1417858 | 0.82 | EGFR (0.82) | EGFRERBB2 | |
| SCHEMBL1417860 | 0.82 | EGFR (0.82) | EGFRERBB2 | |
| SCHEMBL1417992 | 0.80 | EGFR (0.80) | EGFRERBB2 | |
| SCHEMBL1417990 | 0.80 | EGFR (0.80) | EGFRERBB2 | |
| SCHEMBL1418630 | 0.79 | EGFR (0.78) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157011-A1 | 4-AMINO- QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES | Boehringer Ingelheim Pharma KG (DE) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000051991-A1 | 4-AMINO-QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANsSDUCTION MEDIATED BY TYROSINE KINASES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-08 | — | — | WO | disclosed |