Sugi Predict

Sugi Predict / Compounds / 7-Methyl-8-Oxo-5-P-Tolyl-7,8-Dihydro-[1,7]Naphthyridine-6-Carboxylic Acid (3,5-Bis-Trifluoromethyl-Benzyl)-Methyl-Amide (Structural Mix)

7-Methyl-8-Oxo-5-P-Tolyl-7,8-Dihydro-[1,7]Naphthyridine-6-Carboxylic Acid (3,5-Bis-Trifluoromethyl-Benzyl)-Methyl-Amide (Structural Mix)

7-Methyl-8-Oxo-5-P-Tolyl-7,8-Dihydro-[1,7]Naphthyridine-6-Carboxylic Acid (3,5-Bis-Trifluoromethyl-Benzyl)-Methyl-Amide (Structural Mix)

SCHEMBL7850311

Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ TACR1 P25103 19/20 1.00
▸ CENPE Q02224 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7850073 0.93 TACR1 (0.87) TACR1CENPE
SCHEMBL7841636 0.93 TACR1 (1.00) TACR1CENPE
SCHEMBL7841677 0.93 TACR1 (1.00) TACR1CENPE
SCHEMBL7851580 0.92 TACR1 (0.85) TACR1CENPE
SCHEMBL7851529 0.92 TACR1 (0.87) TACR1CENPE
SCHEMBL7841614 0.91 TACR1 (0.83) TACR1CENPE
SCHEMBL7854102 0.89 TACR1 (0.81) TACR1CENPE
SCHEMBL7855109 0.89 TACR1 (1.00) TACR1CENPE
SCHEMBL7851451 0.89 TACR1 (0.84) TACR1CENPE
SCHEMBL7851758 0.88 TACR1 (1.00) TACR1CENPE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0652218-B1 Heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2001-07-11 — — EP claimed
EP-1080087-A4 NOVEL 2-ALKYL SUBSTITUTED IMIDAZOLE COMPOUNDS SMITHKLINE BEECHAM CORP (US) 2001-11-21 — — EP disclosed
EP-0652218-B1 Heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2001-07-11 — — EP disclosed
EP-1080087-A1 NOVEL 2-ALKYL SUBSTITUTED IMIDAZOLE COMPOUNDS SmithKline Beecham Corporation (US) 2001-03-07 — — EP disclosed
WO-1999061437-A1 NOVEL 2-ALKYL SUBSTITUTED IMIDAZOLE COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 1999-12-02 — — WO disclosed
US-5585385-A USEFUL IN TREATING DISORDERS OF MICTURITION; ADMINISTERING TO INHIBIT PLASMA EXTRAVASATION TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-12-17 — — US disclosed
EP-0652218-A1 Heterocyclic compounds, their production and use Takeda Chemical Industries, Ltd. (JP) 1995-05-10 — — EP disclosed