Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.76 |
| ▸ | MEN1 | O00255 | 3/20 | 0.76 |
| ▸ | KDM1A | O60341 | 2/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | CA1 | P00915 | 2/20 | 0.68 |
| ▸ | CA2 | P00918 | 2/20 | 0.68 |
| ▸ | CA7 | P43166 | 2/20 | 0.68 |
| ▸ | CA9 | Q16790 | 2/20 | 0.68 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.65 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.60 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.60 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.60 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.60 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.60 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.60 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.60 |
| ▸ | MAOA | P21397 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28682324 | 0.88 | KMT2A (0.76) | KMT2AMEN1KDM1AGAACA1 | |
| SCHEMBL11711099 | 0.87 | KMT2A (0.74) | KMT2AMEN1KDM1AGAACA1 | |
| SCHEMBL30789064 | 0.87 | KMT2A (0.74) | KMT2AMEN1KDM1AGAACA1 | |
| SCHEMBL22728797 | 0.87 | KMT2A (0.74) | KMT2AMEN1KDM1AGAACA1 | |
| SCHEMBL11713299 | 0.87 | KMT2A (0.74) | KMT2AMEN1KDM1AGAACA1 | |
| SCHEMBL15558738 | 0.87 | KMT2A (0.74) | KMT2AMEN1KDM1AGAACA1 | |
| SCHEMBL24724688 | 0.87 | KMT2A (0.74) | KMT2AMEN1KDM1AGAACA1 | |
| SCHEMBL7849270 | 0.87 | KMT2A (1.00) | KMT2AMEN1KDM1AGAACA1 | |
| SCHEMBL14646680 | 0.87 | KMT2A (1.00) | KMT2AMEN1KDM1AGAACA1 | |
| SCHEMBL13804033 | 0.87 | KMT2A (1.00) | KMT2AMEN1KDM1AGAACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109111415-B | Dendrobium alkaloid derivative, preparation method and medical application | 安徽中医药大学 | 2022-08-23 | — | — | CN | disclosed |
| EP-1129076-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS LHRH ANTAGONISTS | ABBOTT LABORATORIES (US) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000029380-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS LHRH ANTAGONISTS | ABBOTT LABORATORIES (US) | 2000-05-25 | — | — | WO | disclosed |
| US-5981521-A | USEFUL FOR TREATING VARIOUS HORMONE DEPENDENT DISEASES, INCLUDING PROSTATE CANCER, ENDOMETRIOSIS, UTERINE FIBROIDS, PRECOCIOUS PUBERTY, BENIGN PROSTATE HYPERTROPY AND IN VITRO FERTILIZATION | ABBOTT LABORATORIES (US) | 1999-11-09 | — | — | US | disclosed |