Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 8/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 6/20 | 0.47 |
| ▸ | EGFR | P00533 | 7/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.46 |
| ▸ | RAF1 | P04049 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4451210 | 0.87 | SRC (0.59) | SRCMAP2K1EGFRERBB2RAF1 | |
| SCHEMBL4443460 | 0.80 | EGFR (0.71) | SRCMAP2K1EGFRERBB2 | |
| SCHEMBL4453726 | 0.79 | SRC (0.66) | SRCMAP2K1EGFRERBB2RAF1 | |
| SCHEMBL2200378 | 0.77 | EGFR (0.66) | SRCMAP2K1EGFRERBB2 | |
| SCHEMBL2203629 | 0.77 | EGFR (0.66) | SRCMAP2K1EGFRERBB2 | |
| SCHEMBL4447122 | 0.76 | MAP2K1 (0.70) | SRCMAP2K1EGFRERBB2RAF1 | |
| SCHEMBL4454949 | 0.76 | SRC (0.59) | SRCMAP2K1EGFRERBB2RAF1 | |
| SCHEMBL4450583 | 0.75 | MAP2K1 (0.75) | SRCMAP2K1EGFRERBB2RAF1 | |
| SCHEMBL2206555 | 0.75 | MAP2K1 (0.75) | SRCMAP2K1EGFRERBB2RAF1 | |
| SCHEMBL4445590 | 0.75 | EGFR (0.61) | SRCMAP2K1EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | American Cyanamid Company (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018761-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-04-06 | — | — | WO | disclosed |