Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 19/20 | 0.65 |
| ▸ | EDNRB | P24530 | 18/20 | 0.58 |
| ▸ | DHPS | P49366 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972781 | 0.92 | EDNRA (0.73) | EDNRAEDNRB | |
| SCHEMBL5496601 | 0.89 | EDNRA (0.68) | EDNRAEDNRB | |
| SCHEMBL5208403 | 0.88 | EDNRA (0.82) | EDNRAEDNRB | |
| SCHEMBL6782354 | 0.87 | EDNRA (0.72) | EDNRAEDNRB | |
| SCHEMBL7892848 | 0.87 | EDNRA (0.63) | EDNRAEDNRB | |
| SCHEMBL7841308 | 0.87 | EDNRA (0.72) | EDNRAEDNRBDHPS | |
| SCHEMBL6178987 | 0.86 | EDNRA (0.64) | EDNRAEDNRB | |
| SCHEMBL5032747 | 0.85 | EDNRA (0.67) | EDNRAEDNRB | |
| SCHEMBL6785297 | 0.85 | EDNRA (0.66) | EDNRAEDNRB | |
| SCHEMBL7852469 | 0.85 | EDNRA (0.60) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713875-B1 | Sulfonamides | HOFFMANN LA ROCHE (CH) | 2001-03-21 | — | — | EP | disclosed |
| US-5837708-A | CARDIOVASCULAR DISORDERS OF HYPERTENSION, ISCHEMIA, ANGINA PECTORIS AND VASOSPASMS | HOFFMANN-LA ROCHE INC. (US) | 1998-11-17 | — | — | US | disclosed |
| WO-1996016963-A1 | SULFONAMIDES AND THEIR USE AS MEDICAMENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-06 | — | — | WO | disclosed |
| EP-0713875-A1 | Sulfonamides | F. Hoffmann-La Roche AG (CH) | 1996-05-29 | — | — | EP | disclosed |