Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 20/20 | 0.89 |
| ▸ | KDR | P35968 | 2/20 | 0.78 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.78 |
| ▸ | MUSK | O15146 | 1/20 | 0.78 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.78 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.78 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.78 |
| ▸ | PAK3 | O75914 | 1/20 | 0.78 |
| ▸ | STK10 | O94804 | 1/20 | 0.78 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.78 |
| ▸ | ABL1 | P00519 | 1/20 | 0.78 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.78 |
| ▸ | LCK | P06239 | 1/20 | 0.78 |
| ▸ | CSF1R | P07333 | 1/20 | 0.78 |
| ▸ | YES1 | P07947 | 1/20 | 0.78 |
| ▸ | LYN | P07948 | 1/20 | 0.78 |
| ▸ | RET | P07949 | 1/20 | 0.78 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.78 |
| ▸ | KIT | P10721 | 1/20 | 0.78 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL769608 | 0.94 | FLT3 (0.89) | FLT3KDRBMPR1BMUSKEPHB6 | |
| SCHEMBL73035 | 0.94 | FLT3 (1.00) | FLT3KDRBMPR1BMUSKEPHB6 | |
| Hydrochloric Acid SCHEMBL73806 | 0.93 | FLT3 (0.99) | FLT3KDRBMPR1BMUSKEPHB6 | |
| SCHEMBL785339 | 0.92 | FLT3 (0.89) | FLT3KDRBMPR1BMUSKEPHB6 | |
| SCHEMBL785402 | 0.92 | FLT3 (0.89) | FLT3KDRBMPR1BMUSKEPHB6 | |
| SCHEMBL785405 | 0.91 | FLT3 (0.87) | FLT3KDRBMPR1BMUSKEPHB6 | |
| SCHEMBL785401 | 0.91 | FLT3 (0.86) | FLT3KDRBMPR1BMUSKEPHB6 | |
| SCHEMBL73476 | 0.89 | FLT3 (1.00) | FLT3KDRBMPR1BMUSKEPHB6 | |
| Hydrochloric Acid SCHEMBL74399 | 0.88 | FLT3 (0.99) | FLT3KDRBMPR1BMUSKEPHB6 | |
| Quizartinib SCHEMBL29349937 | 0.88 | FLT3 (1.00) | FLT3KDRBMPR1BMUSKEPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8551963-B2 | Imidazolothiazole compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2013-10-08 | — | — | US | disclosed |
| US-20120070410-A1 | IMIDAZOLOTHIAZOLE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120070410-A1 | IMIDAZOLOTHIAZOLE COMPOUNDS AND METHODS OF USE THEREOF | GRK2, GRK3, GRK4 | FLT3 189/4885KDR 448/4885BMPR1B 3045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.