Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.78 |
| ▸ | SMO | Q99835 | 2/20 | 0.56 |
| ▸ | BRAF | P15056 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2972993 | 0.92 | MAPK14 (0.87) | MAPK14SMOBRAFKDM4EALDH1A1 | |
| SCHEMBL6476548 | 0.87 | MAPK14 (1.00) | MAPK14SMOBRAFKDM4EALDH1A1 | |
| SCHEMBL6873810 | 0.84 | MAPK14 (0.74) | MAPK14SMOBRAFKDM4EALDH1A1 | |
| SCHEMBL6782690 | 0.80 | MAPK14 (0.85) | MAPK14SMOBRAFKDM4EALDH1A1 | |
| SCHEMBL6475819 | 0.79 | MAPK14 (1.00) | MAPK14SMOBRAFKDM4EALDH1A1 | |
| SCHEMBL2963776 | 0.79 | MAPK14 (0.68) | MAPK14SMOBRAFKDM4EALDH1A1 | |
| SCHEMBL22066261 | 0.78 | MAPK14 (0.64) | MAPK14SMOBRAFKDM4EALDH1A1 | |
| SCHEMBL2978663 | 0.78 | MAPK14 (0.77) | MAPK14SMOBRAFKDM4EALDH1A1 | |
| SCHEMBL27498040 | 0.77 | MAPK14 (0.78) | MAPK14SMOBRAFKDM4EALDH1A1 | |
| SCHEMBL2979735 | 0.77 | MAPK14 (0.70) | MAPK14SMOBRAFKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102743-A1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007980-A1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-02-17 | — | — | WO | disclosed |