Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.55 |
| ▸ | TEK | Q02763 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | SRC | P12931 | 11/20 | 0.54 |
| ▸ | EGFR | P00533 | 10/20 | 0.54 |
| ▸ | ABL1 | P00519 | 9/20 | 0.54 |
| ▸ | ABL2 | P42684 | 9/20 | 0.54 |
| ▸ | RET | P07949 | 2/20 | 0.50 |
| ▸ | KIF5B | P33176 | 2/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868849 | 0.84 | SRC (0.59) | LCKTEKKDRSRCEGFR | |
| SCHEMBL7855168 | 0.83 | SRC (0.57) | LCKTEKKDRSRCEGFR | |
| SCHEMBL23834558 | 0.82 | LCK (0.68) | LCKTEKKDRSRCEGFR | |
| SCHEMBL16930842 | 0.82 | TEK (0.56) | LCKTEKKDRSRCEGFR | |
| SCHEMBL30053991 | 0.82 | LCK (0.68) | LCKTEKKDRSRCEGFR | |
| SCHEMBL8138258 | 0.81 | SRC (0.63) | LCKTEKKDRSRCEGFR | |
| SCHEMBL6461526 | 0.80 | LCK (0.58) | LCKTEKKDRSRCEGFR | |
| SCHEMBL27555127 | 0.79 | IGF1R (0.56) | LCKTEKKDRSRCEGFR | |
| SCHEMBL6461790 | 0.79 | SRC (0.59) | LCKTEKKDRSRCEGFR | |
| SCHEMBL6861366 | 0.79 | SRC (0.59) | LCKTEKKDRSRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1114053-A1 | PYRROLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000017203-A1 | PYRROLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-03-30 | — | — | WO | disclosed |