Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | PRKCB | P05771 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.37 |
| ▸ | STK3 | Q13188 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7855485 | 1.00 | MEN1 (0.48) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL7743110 | 0.83 | MEN1 (0.48) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL7848269 | 0.83 | MEN1 (0.48) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL7855422 | 0.82 | MEN1 (0.47) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL7743118 | 0.79 | MEN1 (0.45) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL30022485 | 0.78 | MAP2K1 (0.63) | MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL7745819 | 0.77 | MEN1 (0.53) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL7737777 | 0.77 | MEN1 (0.45) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5387038 | 0.77 | MEN1 (0.58) | MEN1KMT2ATDP1MAP2K1MAP2K2 | |
| SCHEMBL5387031 | 0.77 | MEN1 (0.58) | MEN1KMT2ATDP1MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000035435-A9 | USE OF A MEK INHIBITOR FOR PREVENTING TRANSPLANT REJECTION | WARNER LAMBERT CO (US) | 2001-03-22 | — | — | WO | claimed |