Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.52 |
| ▸ | JAK1 | P23458 | 10/20 | 0.52 |
| ▸ | JAK2 | O60674 | 5/20 | 0.52 |
| ▸ | TYK2 | P29597 | 3/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7856739 | 0.99 | JAK3 (0.51) | JAK3JAK1JAK2TYK2HPGDS | |
| SCHEMBL3542862 | 0.92 | JAK3 (0.60) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL3535240 | 0.91 | JAK3 (0.60) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL7855244 | 0.89 | JAK3 (0.56) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL7848065 | 0.89 | JAK3 (0.53) | JAK3JAK1JAK2TYK2HPGDS | |
| SCHEMBL3531561 | 0.85 | JAK3 (0.63) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL3535934 | 0.85 | JAK3 (0.63) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL3535693 | 0.84 | JAK3 (0.62) | JAK3JAK1JAK2TYK2HPGDS | |
| SCHEMBL7843868 | 0.81 | JAK3 (0.54) | JAK3JAK1JAK2TYK2HTR1A | |
| SCHEMBL7855280 | 0.81 | JAK3 (0.54) | JAK3JAK1JAK2TYK2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087970-A1 | PYRROLO 2,3-d]PYRIMIDINE COMPOUNDS | Pfizer Products Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065908-A1 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 1999-12-23 | — | — | WO | disclosed |