Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7856781 | 0.89 | EDNRB (0.57) | EDNRAEDNRB | |
| SCHEMBL7858762 | 0.84 | EDNRA (0.69) | EDNRAEDNRB | |
| SCHEMBL7857434 | 0.79 | EDNRB (0.38) | EDNRAEDNRB | |
| SCHEMBL6771184 | 0.78 | EDNRA (0.68) | EDNRAEDNRB | |
| SCHEMBL6771735 | 0.74 | EDNRA (0.67) | EDNRAEDNRB | |
| SCHEMBL8786523 | 0.74 | EDNRA (0.70) | EDNRAEDNRB | |
| SCHEMBL7839143 | 0.71 | EDNRA (0.70) | EDNRAEDNRB | |
| SCHEMBL7857330 | 0.71 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL1390835 | 0.71 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL7860462 | 0.71 | EDNRA (1.00) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069114-A2 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-01-17 | — | — | EP | claimed |
| EP-0870764-A1 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-10-14 | — | — | EP | claimed |
| EP-1069114-A2 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| EP-0870764-A1 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| US-5571821-A | CARDIOVASCULAR DISORDERS TO MODULATE ENDOTHELIN, HYPOTENSIVE AGENTS AND VASOCONSTRICTION | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-11-05 | — | — | US | disclosed |