Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.58 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24963539 | 0.85 | LRRK2 (0.59) | LRRK2MAPK1MAPK11MAPK14 | |
| SCHEMBL7852194 | 0.85 | MAPK11 (0.59) | LRRK2IKBKEMAPK11MAPK14 | |
| SCHEMBL2615985 | 0.80 | CNR2 (0.50) | GRM2 | |
| SCHEMBL3465575 | 0.77 | MAPK1 (0.47) | LRRK2MAPK1MAPK11MAPK14MAPK3 | |
| SCHEMBL5257164 | 0.76 | GRM2 (0.43) | LRRK2MAPK1MAPK11MAPK14MAPK3 | |
| SCHEMBL24963402 | 0.74 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL1553914 | 0.72 | IKBKB (0.52) | LRRK2IKBKEMAPK1 | |
| SCHEMBL6747565 | 0.72 | MAPK14 (0.51) | MAPK1MAPK14GRM2 | |
| SCHEMBL5255541 | 0.71 | GRM2 (0.46) | MAPK1MAPK11MAPK14MAPK3GRM2 | |
| SCHEMBL24964805 | 0.70 | LRRK2 (0.62) | LRRK2MAPK1MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000055-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. Searle & Co. (US) | 2000-05-17 | — | — | EP | claimed |
| WO-1998052940-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE AND CO. (US) | 1998-11-26 | — | — | WO | claimed |
| EP-1144403-A1 | SUBSTITUED PYRAZOLES AS P38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000031063-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-06-02 | — | — | WO | disclosed |