Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.79 |
| ▸ | GSK3A | P49840 | 4/20 | 0.79 |
| ▸ | CDK1 | P06493 | 3/20 | 0.79 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.79 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.79 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.79 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.36 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30175666 | 0.88 | GSK3B (1.00) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL29402871 | 0.88 | GSK3B (1.00) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL4394521 | 0.88 | GSK3B (1.00) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL29408793 | 0.88 | GSK3B (1.00) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL4404418 | 0.88 | GSK3B (0.84) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL7858290 | 0.87 | GSK3B (0.59) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL5094219 | 0.86 | GSK3B (0.79) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL4401821 | 0.86 | GSK3B (0.81) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL5100153 | 0.85 | GSK3B (0.76) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL22191665 | 0.81 | GSK3B (0.79) | GSK3BGSK3ACDK1CCNB2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |