SCHEMBL7859147

SCHEMBL7859147

CC(C)C(NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)cc1)C(C)C)C(=O)C(F)(F)F

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ELANE P08246 20/20 0.72
CTSG P08311 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23777549 1.00 ELANE (0.72) ELANECTSG
SCHEMBL9435994 1.00 ELANE (0.72) ELANECTSG
SCHEMBL18880034 0.94 ELANE (0.68) ELANECTSG
SCHEMBL17378379 0.93 ELANE (0.68) ELANECTSG
SCHEMBL18880033 0.92 ELANE (0.68) ELANECTSG
SCHEMBL7284014 0.87 ELANE (0.91) ELANECTSG
SCHEMBL7437294 0.87 ELANE (0.71) ELANECTSG
SCHEMBL10577567 0.86 ELANE (0.71) ELANECTSG
SCHEMBL7285001 0.86 ELANE (0.66) ELANE
SCHEMBL23969653 0.86 ELANE (0.64) ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0589937-B1 USE OF 4-(4-CHLOROPHENYL-SULPHONYLCARBAMOYL) BENZOYL-L-VALYL-L-PROLINE 1(RS)-(1-TRIFLUOROACETYL-2-METHYLPROPYL) AMIDE FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF VASCULAR DISEASES ZENECA LTD (GB) 2000-03-15 EP claimed
US-5338727-A 4-(4-Chlorophenylsulfonylcarbamoyl)benzoyl-L-valyl-L-proline 1(RS)-(1-trifluoroacetyl-2-methylpropyl)amide or salt IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1994-08-16 US claimed
EP-0589937-A1 USE OF 4-(4-CHLOROPHENYL-SULPHONYLCARBAMOYL) BENZOYL-L-VALYL-L-PROLINE 1($i(RS))-(1-TRIFLUOROACETYL-2-METHYLPROPYL) AMIDE IN THE TREATMENT OF VASCULAR DISEASES ZENECA LIMITED (GB) 1994-04-06 EP claimed
WO-1992022309-A1 USE OF 4-(4-CHLOROPHENYL-SULPHONYLCARBAMOYL) BENZOYL-L-VALYL-L-PROLINE 1(RS)-(1-TRIFLUOROACETYL-2-METHYLPROPYL) AMIDE IN THE TREATMENT OF VASCULAR DISEASES ZENECA LTD. (GB) 1992-12-23 WO claimed
US-5162348-A 4-(4-chlorophenylsulfonylcarbamoyl)benzoyl-L-valyl-L-proline 1(RS)-(1-trifluoroacetyl-2-methylpropyl)-amide IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-11-10 US claimed
US-5128322-A Hemorrhage prevention after leukemia therapy IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-07-07 US claimed
JP-4235134-A None JP disclosed
JP-4235133-A None JP disclosed
JP-4243836-A None JP disclosed
JP-4235132-A None JP disclosed
EP-0762887-B1 ACYLATED ENOL DERIVATIVES AS PRODRUGS OF ELASTASE INHIBITORS MERRELL PHARMA INC (US) 2001-09-26 EP disclosed
US-5972897-A AN ANTIINFLAMMATORY AGENTS TREATING CYSTIC FIBROSIS AND EMPHYSEMA OR BOWEL DISEASES, A NEUTROPHIL ASSOCIATED INFLAMMATORY DISEASE, BRONCHITIS MERRELL PHARMACEUTICALS INC. (US) 1999-10-26 US disclosed
EP-0762887-A4 ACYLATED ENOL DERIVATIVES AS PRODRUGS OF ELASTASE INHIBITORS MERRELL PHARMA INC (US) 1999-03-31 EP disclosed
JP-H04243836-A ACUTE NON-LYMPHOCYTIC LEUKEMIA TREATING AGENT IMPERIAL CHEM IND PLC <ICI> 1992-08-31 JP disclosed
JP-H04235132-A THERAPEUTIC PRODUCT FOR THE TREATMENT OF CYSTIC FIBROSIS IMPERIAL CHEM IND PLC <ICI> 1992-08-24 JP disclosed
JP-H04235134-A THERAPEUTIC AGENT FOR TREATING ADULT RESPIRATORY DISTRESS SYNDROME IMPERIAL CHEM IND PLC <ICI> 1992-08-24 JP disclosed
JP-H04235133-A COMPOUND FOR TREATMENT OF BRONCHITIS IMPERIAL CHEM IND PLC <ICI> 1992-08-24 JP disclosed
US-5128322-A Hemorrhage prevention after leukemia therapy IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-07-07 US disclosed
EP-0463811-A3 4-(4-CHLOROPHENYLSULPHONYLCARBAMOYL)BENZOYL-L-VALYL-L-PROLINE-1-(RS)-(1-TRIFLUOROACETYL-2-METHYLPROPYL)AMIDE FOR TREATING HAEMORRHAGE ASSOCIATED WITH ACUTE NON-LYMPHOCYTIC LEUKAEMIA 1992-04-01 EP disclosed
EP-0463811-A2 4-(4-Chlorophenylsulphonylcarbamoyl)benzoyl-L-valyl-L-proline-1-(RS)-(1-trifluoroacetyl-2-methylpropyl)amide for treating haemorrhage associated with acute non-lymphocytic leukaemia ZENECA LIMITED (GB) 1992-01-02 EP disclosed