Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 8/20 | 0.76 |
| ▸ | RAF1 | P04049 | 6/20 | 0.55 |
| ▸ | KDR | P35968 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | MUSK | O15146 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | MLNR | O43193 | 1/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | PDE6D | O43924 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | CDK14 | O94921 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6815841 | 0.84 | GRM4 (0.51) | GRM4RAF1KDRMEN1KMT2A | |
| SCHEMBL7178922 | 0.83 | GRM4 (0.86) | GRM4KDRMEN1KMT2AEGFR | |
| SCHEMBL6815923 | 0.82 | IL2 (0.53) | GRM4RAF1KDRMEN1KMT2A | |
| SCHEMBL6815329 | 0.82 | KDR (0.56) | GRM4RAF1KDRMEN1KMT2A | |
| SCHEMBL6815779 | 0.78 | KDR (0.54) | GRM4RAF1KDRMEN1KMT2A | |
| SCHEMBL6810963 | 0.76 | NPC1 (0.50) | GRM4MEN1KMT2A | |
| SCHEMBL22216944 | 0.73 | GRM4 (0.76) | GRM4KDRMEN1KMT2AHDAC6 | |
| SCHEMBL3806472 | 0.73 | KDR (0.53) | GRM4KDRMEN1KMT2ACA7 | |
| SCHEMBL3275819 | 0.73 | KDR (0.53) | GRM4KDRMEN1KMT2ACA7 | |
| SCHEMBL11613550 | 0.73 | GRM4 (0.61) | GRM4RAF1KDRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137645-A2 | ALPHA-METHYLBENZYL-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000034260-A2 | ALPHA-METHYLBENZYL-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |