Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 3/20 | 0.65 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 7/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7859389 | 1.00 | CXCR1 (0.65) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7859387 | 1.00 | CXCR1 (0.65) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7859852 | 0.88 | CXCR1 (0.68) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7861107 | 0.84 | CXCR1 (0.63) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL7488280 | 0.82 | CXCR1 (0.65) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL3461321 | 0.81 | HSD17B10 (0.70) | MEN1KMT2AHSD17B10MAPTLMNA | |
| SCHEMBL10577831 | 0.81 | HSD17B10 (0.70) | MEN1KMT2AHSD17B10MAPTLMNA | |
| SCHEMBL7861284 | 0.81 | CXCR1 (0.59) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL5595104 | 0.80 | CXCR1 (0.80) | CXCR1CXCR2MEN1KMT2ATDP1 | |
| SCHEMBL10572874 | 0.80 | HSD17B10 (0.57) | CXCR1CXCR2MEN1KMT2ACRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915651-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6271261-B1 | CHEMOKINE MEDIATED DISEASES, BINDING INTERLEUKINS OR BETA-RECEPTORS AND ADMINISTERING TO MAMMALS | SMITHKLINE BEECHAM CORPORATION | 2001-08-07 | — | — | US | disclosed |
| EP-0915651-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997049286-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-31 | — | — | WO | disclosed |