Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diltiazem. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1S known ✓ | Q13698 | 11/20 | 0.96 |
| ▸ | CACNA1F known ✓ | O60840 | 1/20 | 0.96 |
| ▸ | CACNA1D known ✓ | Q01668 | 1/20 | 0.96 |
| ▸ | CACNA1C known ✓ | Q13936 | 1/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.96 |
| ▸ | TSHR | P16473 | 2/20 | 0.96 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.96 |
| ▸ | LMNA | P02545 | 2/20 | 0.96 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.96 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.96 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.96 |
| ▸ | HRH2 | P25021 | 1/20 | 0.96 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.96 |
| ▸ | SCN1A | P35498 | 1/20 | 0.96 |
| ▸ | SCN4A | P35499 | 1/20 | 0.96 |
| ▸ | HTT | P42858 | 1/20 | 0.96 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.96 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.96 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.96 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diltiazem SCHEMBL17776 | 0.98 | CACNA1S (1.00) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Diltiazem SCHEMBL13575826 | 0.98 | CACNA1S (1.00) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Diltiazem SCHEMBL30127237 | 0.98 | CACNA1S (1.00) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Diltiazem SCHEMBL30127157 | 0.98 | CACNA1S (1.00) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Diltiazem SCHEMBL614334 | 0.98 | CACNA1S (1.00) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Diltiazem SCHEMBL29353951 | 0.98 | CACNA1S (1.00) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Diltiazem SCHEMBL4886734 | 0.98 | CACNA1S (1.00) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Diltiazem SCHEMBL676914 | 0.98 | CACNA1S (1.00) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Diltiazem SCHEMBL3468378 | 0.98 | CACNA1S (1.00) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Diltiazem SCHEMBL10831293 | 0.97 | CYP3A4 (1.00) | CACNA1SCYP3A4TSHRABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835097-B1 | MIXED LIPID-BICARBONATE COLLOIDAL PARTICLES FOR DELIVERING DRUGS OR CALORIES | BIOMOLECULAR PRODUCTS INC (US) | 2001-08-29 | — | — | EP | disclosed |
| US-5891466-A | FATTY ACID, MONOGLYCERIDE, LYSOPHOSPHATIDYL CHOLINE, BICARBONATE | BIOMOLECULAR PRODUCTS, INC. | 1999-04-06 | — | — | US | disclosed |
| US-5741822-A | Mixed lipid-bicarbonate colloidal particles for delivering drugs | BIOMOLECULAR PRODUCTS, INC. | 1998-04-21 | — | — | US | disclosed |
| EP-0835097-A2 | MIXED LIPID-BICARBONATE COLLOIDAL PARTICLES FOR DELIVERING DRUGS OR CALORIES | Biomolecular Products, Inc. (US) | 1998-04-15 | — | — | EP | disclosed |
| US-5707873-A | Method of accessing mixed lipid transport properties of a drug | BIOMOLECULAR PRODUCTS, INC. | 1998-01-13 | — | — | US | disclosed |
| WO-1996039120-A2 | MIXED LIPID-BICARBONATE COLLOIDAL PARTICLES FOR DELIVERING DRUGS OR CALORIES | BIOMOLECULAR PRODUCTS, INC. (US) | 1996-12-12 | — | — | WO | disclosed |
| US-5571517-A | Mixed lipid-bicarbonate colloidal particles for delivering drugs or calories | BIOMOLECULAR PRODUCTS, INC. | 1996-11-05 | — | — | US | disclosed |
| EP-0543943-B1 | MIXED LIPID-BICARBONATE COLLOIDAL PARTICLES FOR DELIVERING DRUGS OR CALORIES | YESAIR DAVID W (US) | 1995-04-26 | — | — | EP | disclosed |
| US-5314921-A | Vehicle for oral administered drugs | BIOMOLECULAR PRODUCTS, INC. | 1994-05-24 | — | — | US | disclosed |
| EP-0543943-A1 | MIXED LIPID-BICARBONATE COLLOIDAL PARTICLES FOR DELIVERING DRUGS OR CALORIES. | YESAIR DAVID W (US) | 1993-06-02 | — | — | EP | disclosed |
| WO-1992003121-A1 | MIXED LIPID-BICARBONATE COLLOIDAL PARTICLES FOR DELIVERING DRUGS OR CALORIES | YESAIR DAVID W (US) | 1992-03-05 | — | — | WO | disclosed |