Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 9/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 8/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 14/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 10/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8500685 | 0.79 | MEN1 (0.33) | MEN1TSHRKMT2ACHRM2CHRM5 | |
| Iodide SCHEMBL8468039 | 0.79 | MEN1 (0.33) | MEN1TSHRKMT2ACHRM2CHRM5 | |
| SCHEMBL8498316 | 0.77 | MEN1 (0.33) | MEN1TSHRKMT2ACHRM2CHRM5 | |
| SCHEMBL8465914 | 0.77 | MEN1 (0.33) | MEN1TSHRKMT2ACHRM2CHRM5 | |
| Hydrochloric Acid SCHEMBL8498376 | 0.76 | MEN1 (0.33) | MEN1TSHRKMT2A | |
| Bromide SCHEMBL7853038 | 0.75 | — | — | |
| Iodide SCHEMBL8468496 | 0.64 | MEN1 (0.33) | MEN1TSHRKMT2A | |
| Iodide SCHEMBL8387854 | 0.64 | MEN1 (0.33) | MEN1TSHRKMT2A | |
| SCHEMBL8467964 | 0.63 | MEN1 (0.32) | MEN1TSHRKMT2A | |
| SCHEMBL7605118 | 0.62 | NPSR1 (0.50) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788362-B1 | PHOSPONOCARBOXYLATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | PROCTER & GAMBLE PHARMA (US) | 2001-07-25 | — | — | EP | disclosed |
| US-5760021-A | TREATING OR PREVENTING METABOLIC BONE DISORDERS | THE PROCTER & GAMBLE COMPANY (US) | 1998-06-02 | — | — | US | disclosed |
| EP-0788362-A1 | PHOSPONOCARBOXYLATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1997-08-13 | — | — | EP | disclosed |
| WO-1993024131-A1 | PHOSPONOCARBOXYLATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1993-12-09 | — | — | WO | disclosed |