SCHEMBL786115 — predicted protein targets

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	METAP1	P53582	1/20	0.54

▸	NR1I3	Q14994	1/20	0.50

▸	PDE5A	O76074	6/20	0.46

▸	ABCG2	Q9UNQ0	4/20	0.46

▸	TGFBR1	P36897	1/20	0.45

▸	MAOA	P21397	1/20	0.44

▸	MAOB	P27338	1/20	0.44

▸	ATM	Q13315	1/20	0.43

▸	HTT	P42858	2/20	0.43

▸	NPC1	O15118	1/20	0.43

▸	MAPK1	P28482	1/20	0.43

▸	RAB9A	P51151	1/20	0.43

▸	MEN1	O00255	1/20	0.43

▸	KMT2A	Q03164	1/20	0.43

▸	KDM4E	B2RXH2	1/20	0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL11826398	0.86	NR1I3 (0.67)	METAP1NR1I3PDE5AABCG2TGFBR1
SCHEMBL21679742	0.86	METAP1 (0.54)	METAP1NR1I3PDE5AABCG2MAOA
SCHEMBL27713976	0.85	NR1I3 (0.58)	NR1I3ABCG2ATMMAPK1MEN1
SCHEMBL16404333	0.85	METAP1 (0.61)	METAP1PDE5AABCG2MAOAMAOB
SCHEMBL384799	0.85	METAP1 (0.61)	METAP1PDE5AABCG2MAOAMAOB
SCHEMBL4847197	0.84	ATM (0.59)	METAP1PDE5AABCG2ATMHTT
SCHEMBL29593068	0.84	ATM (0.59)	METAP1PDE5AABCG2ATMHTT
SCHEMBL25463096	0.81	MEN1 (0.57)	METAP1PDE5AABCG2ATMHTT
SCHEMBL17275213	0.81	METAP1 (0.57)	METAP1PDE5AABCG2ATMHTT
SCHEMBL16768514	0.81	METAP1 (0.53)	METAP1NR1I3PDE5AABCG2TGFBR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-8633210-B2	Triazole compounds useful as protein kinase inhibitors	VERTEX PHARMACEUTICALS INCORPORATED (US)	2014-01-21	—	—	US	disclosed
US-8524720-B2	Substituted N-(pyrazol-5-yl)-pyrrolo[3,2-D]pyrimidin-4-amine useful as protein kinase inhibitors	VERTEX PHARMACEUTICALS INCORPORATED (US)	2013-09-03	—	—	US	disclosed
US-20120071657-A1	TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS	VERTEX PHARMACEUTICALS INCORPORATED (US)	2012-03-22	—	—	US	disclosed
US-7951820-B2	Triazole compounds useful as protein kinase inhibitors	VERTEX PHARMACEUTICALS INCORPORATED (US)	2011-05-31	—	—	US	disclosed
EP-1317448-B2	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS	VERTEX PHARMA (US)	2011-05-04	—	—	EP	disclosed
US-20100256170-A1	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS	VERTEX PHARMACEUTICALS INCORPORATED (US)	2010-10-07	—	—	US	disclosed
US-7691853-B2	Pyrazole compounds useful as protein kinase inhibitors	VERTEX PHARMACEUTICALS INCORPORATED (US)	2010-04-06	—	—	US	disclosed
US-7473691-B2	Pyrazole compounds useful as protein kinase inhibitors	VERTEX PHARMACEUTICALS INCORPORATED (US)	2009-01-06	—	—	US	disclosed
US-7390815-B2	Pyrazole compounds useful as protein kinase inhibitors	VERTEX PHARMACEUTICALS INCORPORATED (US)	2008-06-24	—	—	US	disclosed
US-20070270444-A1	Pyrazole compounds useful as protein kinase inhibitors	VERTEX PHARMACEUTICALS INCORPORATED	2007-11-22	—	—	US	disclosed
US-20030064981-A1	Pyrazole compounds useful as protein kinase inhibitors	VERTEX PHARMACEUTICALS INCORPORATED	2003-04-03	—	—	US	disclosed
US-20030055044-A1	Pyrazole compounds useful as protein kinase inhibitors	VERTEX PHARMACEUTICALS INCORPORATED	2003-03-20	—	—	US	disclosed
WO-2002022605-A1	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS	VERTEX PHARMACEUTICALS INCORPORATED (US)	2002-03-21	—	—	WO	disclosed
WO-2002022604-A1	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS	VERTEX PHARMACEUTICALS INCORPORATED (US)	2002-03-21	—	—	WO	disclosed
WO-2002022606-A1	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS	VERTEX PHARMACEUTICALS INCORPORATED (US)	2002-03-21	—	—	WO	disclosed
WO-2002022607-A1	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS	VERTEX PHARMACEUTICALS INCORPORATED (US)	2002-03-21	—	—	WO	disclosed
WO-2002022603-A1	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS	VERTEX PHARMACEUTICALS INCORPORATED (US)	2002-03-21	—	—	WO	disclosed
WO-2002022602-A2	TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS	VERTEX PHARMACEUTICALS INCORPORATED (US)	2002-03-21	—	—	WO	disclosed
WO-2002022608-A1	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS	VERTEX PHARMACEUTICALS INCORPORATED (US)	2002-03-21	—	—	WO	disclosed
WO-2002022601-A1	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS	VERTEX PHARMACEUTICALS INCORPORATED (US)	2002-03-21	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20030064981-A1	Pyrazole compounds useful as protein kinase inhibitors	AURKC, AURKA, GSK3A	METAP1 4140/4885NR1I3 484/4885PDE5A 3861/4885
US-20100256170-A1	PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS	GSK3B, CDK3, GSK3A	METAP1 4437/4885NR1I3 734/4885PDE5A 4214/4885
US-20120071657-A1	TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS	GSK3B, GSK3A, CDK19	METAP1 2882/4885NR1I3 602/4885PDE5A 3100/4885
US-20030055044-A1	Pyrazole compounds useful as protein kinase inhibitors	AURKC, AURKA, GSK3B	METAP1 4152/4885NR1I3 832/4885PDE5A 4073/4885
US-20070270444-A1	Pyrazole compounds useful as protein kinase inhibitors	GSK3B, CDK3, GSK3A	METAP1 4437/4885NR1I3 734/4885PDE5A 4214/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.