Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 7/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861484 | 1.00 | TACR1 (0.45) | TACR1HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL7861479 | 1.00 | TACR1 (0.45) | TACR1HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL7861787 | 1.00 | TACR1 (0.45) | TACR1HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL7861794 | 1.00 | TACR1 (0.45) | TACR1HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL7864916 | 0.91 | HRH1 (0.45) | TACR1HRH1KCNH2IRAK4SSTR5 | |
| SCHEMBL7864920 | 0.91 | HRH1 (0.45) | TACR1HRH1KCNH2IRAK4SSTR5 | |
| SCHEMBL7864923 | 0.91 | HRH1 (0.45) | TACR1HRH1KCNH2IRAK4SSTR5 | |
| SCHEMBL7862632 | 0.82 | HRH1 (0.43) | TACR1HRH1KCNH2IRAK4SSTR5 | |
| SCHEMBL7862634 | 0.82 | HRH1 (0.43) | TACR1HRH1KCNH2IRAK4SSTR5 | |
| SCHEMBL8714245 | 0.82 | HRH1 (0.43) | TACR1HRH1KCNH2IRAK4SSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869955-B1 | N-ACYL-2-SUBSTITUTED-4-(BENZIMIDAZOLYL- OR IMIDAZOPYRIDINYL-SUBSTITUTED RESIDUES)-PIPERIDINES AS TACHYKININ ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2001-10-24 | — | — | EP | disclosed |
| US-6110939-A | AS A SUBSTANCE P ANTAGONISTS TREATING TACHYKININ-MEDIATED DISEASE, ASTHMA, CENTRAL NERVOUS SYSTEM DISORDER | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-08-29 | — | — | US | disclosed |