Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.56 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16709591 | 0.86 | HTT (0.58) | ALDH1A1HTTKMT2AMEN1TDP1 | |
| SCHEMBL7550117 | 0.84 | CXCR1 (0.61) | ALDH1A1HTTCXCR1CXCR2KMT2A | |
| SCHEMBL7860999 | 0.82 | CXCR1 (0.62) | HTTCXCR1CXCR2KMT2AMEN1 | |
| SCHEMBL8194387 | 0.81 | MAPT (0.58) | ALDH1A1HTTCXCR1CXCR2KMT2A | |
| SCHEMBL5595104 | 0.81 | CXCR1 (0.80) | ALDH1A1HTTCXCR1CXCR2KMT2A | |
| SCHEMBL7864076 | 0.81 | CXCR1 (0.54) | ALDH1A1HTTCXCR1CXCR2KMT2A | |
| SCHEMBL7859962 | 0.79 | CXCR1 (0.65) | ALDH1A1HTTCXCR1CXCR2KMT2A | |
| SCHEMBL17085327 | 0.78 | HTT (0.71) | ALDH1A1HTTCXCR1CXCR2KMT2A | |
| SCHEMBL5594951 | 0.78 | HTT (0.71) | ALDH1A1HTTCXCR1CXCR2KMT2A | |
| SCHEMBL8207155 | 0.77 | CXCR1 (0.62) | ALDH1A1HTTCXCR1CXCR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912505-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6133319-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-17 | — | — | US | disclosed |
| US-6113825-A | MELT SPINNING | SHELL OIL COMPANY (US) | 2000-09-05 | — | — | US | disclosed |
| EP-0912505-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997049680-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-31 | — | — | WO | disclosed |