Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | CNR1 | P21554 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | CBLB | Q13191 | 1/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.49 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15006459 | 0.81 | GRM5 (0.47) | GRM5POLBSMN1; SMN2CNR1RAB9A | |
| SCHEMBL13201029 | 0.80 | POLB (0.77) | GRM5POLBSMN1; SMN2CNR1RAB9A | |
| SCHEMBL30761113 | 0.80 | POLB (0.77) | GRM5POLBSMN1; SMN2CNR1RAB9A | |
| SCHEMBL10134797 | 0.79 | CDK2 (0.57) | GRM5POLBSMN1; SMN2CNR1RAB9A | |
| SCHEMBL3870458 | 0.79 | GRM5 (1.00) | GRM5SMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL10134862 | 0.76 | POLB (0.51) | POLBSMN1; SMN2CNR1RAB9ANPC1 | |
| SCHEMBL10134912 | 0.76 | POLB (0.51) | POLBSMN1; SMN2CNR1RAB9ANPC1 | |
| SCHEMBL13097165 | 0.75 | GRM5 (0.54) | GRM5POLBCNR1RAB9ANPC1 | |
| SCHEMBL22130325 | 0.75 | SMN1; SMN2 (0.72) | SMN1; SMN2CNR1RAB9ANPC1KDM4E | |
| SCHEMBL16420803 | 0.75 | IRAK4 (0.63) | CNR1RAB9ANPC1SCN2ASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010128058-A1 | DIHYDROPYRIMIDINONES FOR USE AS BACE2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-11 | — | — | WO | disclosed |