Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.44 |
| ▸ | EGFR | P00533 | 11/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20051025 | 0.86 | LCK (0.46) | LCKEGFRSRCGAKKDR | |
| SCHEMBL1260737 | 0.85 | ENPP1 (0.54) | LCKEGFRSRCGAKKDR | |
| SCHEMBL12779104 | 0.82 | KDR (0.48) | LCKEGFRSRCGAKKDR | |
| SCHEMBL11315816 | 0.79 | EGFR (0.52) | LCKEGFRGAKKDRRET | |
| SCHEMBL20050180 | 0.79 | KDR (0.43) | LCKEGFRSRCGAKKDR | |
| SCHEMBL24393302 | 0.77 | ENPP1 (0.54) | LCKEGFRKDRENPP1CSF1R | |
| SCHEMBL24393297 | 0.77 | ENPP1 (0.70) | LCKEGFRSRCKDRENPP1 | |
| SCHEMBL24009138 | 0.76 | EGFR (0.54) | EGFRSRCKDRPDGFRBENPP1 | |
| SCHEMBL19381685 | 0.76 | EGFR (0.50) | LCKEGFRSRCGAKKDR | |
| SCHEMBL20355006 | 0.76 | EGFR (0.46) | LCKEGFRSRCGAKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010135524-A1 | BENZOXAZEPINES BASED P13K/MT0R INHIBITORS AGAINST PROLIFERATIVE DISEASES | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |