Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861741 | 1.00 | KCNH2 (0.43) | KCNH2NR4A2HRH1KDM4EIRAK4 | |
| SCHEMBL7854951 | 0.89 | KDM4E (0.45) | KCNH2NR4A2HRH1KDM4ECHRM1 | |
| SCHEMBL7854950 | 0.89 | KDM4E (0.45) | KCNH2NR4A2HRH1KDM4ECHRM1 | |
| Oxalic Acid SCHEMBL7864912 | 0.85 | HRH1 (0.45) | KCNH2NR4A2HRH1KDM4EIRAK4 | |
| Oxalic Acid SCHEMBL7864914 | 0.85 | HRH1 (0.45) | KCNH2NR4A2HRH1KDM4EIRAK4 | |
| SCHEMBL8713508 | 0.82 | IRAK4 (0.41) | HRH1KDM4EIRAK4 | |
| SCHEMBL7861794 | 0.81 | TACR1 (0.45) | KCNH2HRH1IRAK4 | |
| SCHEMBL7861479 | 0.81 | TACR1 (0.45) | KCNH2HRH1IRAK4 | |
| SCHEMBL7861484 | 0.81 | TACR1 (0.45) | KCNH2HRH1IRAK4 | |
| SCHEMBL7861787 | 0.81 | TACR1 (0.45) | KCNH2HRH1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869955-B1 | N-ACYL-2-SUBSTITUTED-4-(BENZIMIDAZOLYL- OR IMIDAZOPYRIDINYL-SUBSTITUTED RESIDUES)-PIPERIDINES AS TACHYKININ ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2001-10-24 | — | — | EP | disclosed |