Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | GPR142 | Q7Z601 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 3/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7878884 | 0.92 | PIK3CA (0.48) | PIK3CAPIK3CGCREBBPGPR142LMNA | |
| SCHEMBL13173995 | 0.90 | PIK3CA (0.46) | PIK3CAPIK3CGCREBBPGPR142LMNA | |
| SCHEMBL13173994 | 0.87 | PIK3CA (0.48) | PIK3CACREBBPGPR142LMNAPOLB | |
| SCHEMBL3792896 | 0.87 | PIK3CA (0.59) | PIK3CACREBBP | |
| SCHEMBL7878242 | 0.85 | PIK3CA (0.48) | PIK3CAPIK3CGCREBBPGPR142LMNA | |
| SCHEMBL12979899 | 0.84 | PIK3CA (0.50) | PIK3CAPIK3CGCREBBPGPR142 | |
| SCHEMBL13174050 | 0.83 | PIK3CA (0.46) | PIK3CAPIK3CGCREBBPGPR142LMNA | |
| SCHEMBL15433927 | 0.83 | PIK3CG (0.41) | PIK3CAPIK3CGLMNAPOLBHPGD | |
| SCHEMBL13173983 | 0.82 | PIK3CA (0.48) | PIK3CACREBBPGPR142LMNAPOLB | |
| SCHEMBL7877195 | 0.82 | PIK3CA (0.48) | PIK3CAPIK3CGCREBBPGPR142LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138490-A1 | BENZOXAZEPINES AS INHIBITORS OF MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2010-12-02 | — | — | WO | disclosed |