SCHEMBL7861826

SCHEMBL7861826

CO[Si](C)(CCCc1ccc(N)cc1)OC

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.47
GFER P55789 1/20 0.46
CYP19A1 P11511 5/20 0.44
MAOA P21397 2/20 0.41
TAAR1 Q96RJ0 1/20 0.37
ALDH1A1 P00352 2/20 0.37
CYP3A4 P08684 1/20 0.37
TSHR P16473 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
HTR2A P28223 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
LOXL2 Q9Y4K0 1/20 0.35
RECQL P46063 1/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
USP2 O75604 1/20 0.35
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.35
HPGD P15428 1/20 0.35
RAB9A P51151 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8953980 0.89 GFER (0.50) MAOBGFERCYP19A1MAOATAAR1
SCHEMBL6879739 0.83 CYP19A1 (0.50) MAOBGFERCYP19A1MAOATAAR1
SCHEMBL7858996 0.82 MAOB (0.44) MAOBGFERCYP19A1MAOATAAR1
SCHEMBL15735070 0.81 TAAR1 (0.41) MAOBCYP19A1TAAR1ALDH1A1GAA
SCHEMBL1068905 0.81 IDO1 (0.44) MAOBMAOASIGMAR1MEN1KMT2A
SCHEMBL7128858 0.80 MAOB (0.42) MAOBGFERCYP19A1MAOAALDH1A1
SCHEMBL3911466 0.79 HRH1 (0.46) ALDH1A1CYP3A4TSHRTDP1SIGMAR1
SCHEMBL9074670 0.79 CYP19A1 (0.38) MAOBCYP19A1MAOACYP3A4SIGMAR1
SCHEMBL163507 0.78 TAAR1 (0.37) MAOBCYP19A1TAAR1SIGMAR1KDM4E
SCHEMBL15734316 0.77 TAAR1 (0.46) MAOBTAAR1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6238752-B1 MODIFIED DIAMINE CHISSO CORPORATION (JP) 2001-05-29 US disclosed
EP-1020442-A1 NOVEL DIAMINO COMPOUNDS, POLYAMIC ACID, POLYIMIDE, LIQUID-CRYSTAL ALIGNMENT FILM MADE FROM FILM OF THE POLYIMIDE, AND LIQUID-CRYSTAL DISPLAY ELEMENT CONTAINING THE ALIGNMENT FILM Chisso Corporation (JP) 2000-07-19 EP disclosed
US-5807961-A Polyamic acid, polyimide film and liquid crystal aligning film and liquid crystal display element using the formers CHISSO CORPORATION (JP) 1998-09-15 US disclosed
EP-0601813-B1 Diamino compounds and their production method and liquid crystal alignment layers using the compounds CHISSO CORP (JP) 1997-08-13 EP disclosed
US-5501884-A Diamino compounds and their production method and liquid crystal alignment layers using the compounds CHISSO CORPORATION (JP) 1996-03-26 US disclosed
US-5430195-A Diamino compounds and liquid crystal aligning films CHISSO CORPORATION (JP) 1995-07-04 US disclosed
US-5414126-A Diamino compounds and liquid crystal aligning films CHISSO CORPORATION (JP) 1995-05-09 US disclosed
US-5382688-A Diamino compounds and their production method CHISSO CORPORATION (JP) 1995-01-17 US disclosed
EP-0601813-A1 Diamino compounds and their production method and liquid crystal alignment layers using the compounds CHISSO CORPORATION (JP) 1994-06-15 EP disclosed