SCHEMBL7861830

SCHEMBL7861830

O=[N+]([O-])c1cccc(CNN(Cc2ccccc2)[N+](=O)[O-])c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 3/20 0.57
CYP1A2 P05177 2/20 0.57
CYP2D6 P10635 2/20 0.57
CYP2C9 P11712 2/20 0.57
ALDH1A1 P00352 3/20 0.54
LMNA P02545 1/20 0.54
POLB P06746 1/20 0.51
KDM1A O60341 2/20 0.50
MAOA P21397 2/20 0.50
MAOB P27338 2/20 0.50
ACKR3 P25106 1/20 0.49
TSHR P16473 1/20 0.49
MEN1 O00255 2/20 0.48
MAPT P10636 2/20 0.48
KMT2A Q03164 2/20 0.48
PTPN1 P18031 1/20 0.47
OPRM1 P35372 1/20 0.46
OPRK1 P41145 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP19A1 P11511 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1039984 0.77 TSHR (0.59) CYP2C19CYP1A2CYP2D6CYP2C9ALDH1A1
SCHEMBL30482083 0.77 TSHR (0.59) CYP2C19CYP1A2CYP2D6CYP2C9ALDH1A1
SCHEMBL6675949 0.75 CYP1A2 (0.73) CYP2C19CYP1A2CYP2D6CYP2C9ALDH1A1
SCHEMBL7338580 0.75 PTPRF (0.69) ALDH1A1KDM1AMAOAMAOBTSHR
SCHEMBL6675948 0.72 MEN1 (0.66) ALDH1A1POLBKDM1AMAOAMAOB
SCHEMBL1829879 0.72 TSHR (0.61) CYP2C19CYP1A2CYP2D6CYP2C9ALDH1A1
SCHEMBL13219674 0.72 TSHR (0.66) CYP2C19CYP1A2CYP2D6CYP2C9ALDH1A1
SCHEMBL28219453 0.72 TSHR (0.61) CYP2C19CYP1A2CYP2D6CYP2C9ALDH1A1
SCHEMBL28219452 0.72 TSHR (0.61) CYP2C19CYP1A2CYP2D6CYP2C9ALDH1A1
SCHEMBL2565526 0.72 KMT2A (0.61) CYP2C19CYP1A2CYP2D6CYP2C9ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1067928-A4 METHODS FOR INHIBITING MRP1 LILLY CO ELI (US) 2001-11-14 EP disclosed
EP-1067928-A1 METHODS FOR INHIBITING MRP1 ELI LILLY AND COMPANY (US) 2001-01-17 EP disclosed
WO-1999051228-A1 METHODS FOR INHIBITING MRP1 ELI LILLY AND COMPANY (US) 1999-10-14 WO disclosed