Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 13/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | GABRP | O00591 | 2/20 | 0.32 |
| ▸ | GABRD | O14764 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.32 |
| ▸ | GABRE | P78334 | 2/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.32 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8470935 | 0.86 | FOLH1 (0.36) | FOLH1MEN1GAAKMT2AGRM3 | |
| SCHEMBL7541169 | 0.85 | FOLH1 (0.33) | FOLH1MEN1GAAKMT2ACYP1A2 | |
| SCHEMBL28570650 | 0.80 | HDAC1 (0.42) | FOLH1MEN1GAAKMT2ACYP1A2 | |
| SCHEMBL4537975 | 0.78 | FOLH1 (0.40) | FOLH1MEN1GAAKMT2AGRM3 | |
| SCHEMBL7854834 | 0.77 | FOLH1 (0.34) | FOLH1MEN1GAAKMT2AGRM3 | |
| SCHEMBL7536923 | 0.76 | FOLH1 (0.55) | FOLH1GRM3CYP1A2GRM8GRM6 | |
| SCHEMBL11420045 | 0.76 | KMT2A (0.37) | FOLH1KMT2A | |
| SCHEMBL764175 | 0.76 | FOLH1 (0.39) | FOLH1CYP1A2GABRPGABRDGABRA1 | |
| SCHEMBL16350134 | 0.76 | FOLH1 (0.39) | FOLH1CYP1A2GABRPGABRDGABRA1 | |
| SCHEMBL4537931 | 0.74 | FOLH1 (0.37) | FOLH1MEN1GAAKMT2AGRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1093453-A1 | NAALADASE INHIBITORS USEFUL AS PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS | GUILFORD PHARMACEUTICALS INC. (US) | 2001-04-25 | — | — | EP | disclosed |
| WO-2000001668-A2 | NAALADASE INHIBITORS USEFUL AS PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS | GUILFORD PHARMACEUTICALS INC. (US) | 2000-01-13 | — | — | WO | disclosed |