Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 17/20 | 0.72 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CCND1 | P24385 | 2/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | PRKACG | P22612 | 1/20 | 0.44 |
| ▸ | PRKACB | P22694 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7030485 | 0.93 | TOP1 (0.74) | TOP1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL5666580 | 0.90 | TOP1 (0.67) | TOP1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL5668290 | 0.90 | TOP1 (0.67) | TOP1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL5666540 | 0.87 | TOP1 (0.75) | TOP1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL7025632 | 0.87 | TOP1 (0.75) | TOP1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL5664818 | 0.86 | TOP1 (0.73) | TOP1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL7855047 | 0.85 | TOP1 (0.87) | TOP1PRKCAEGFR | |
| SCHEMBL5668292 | 0.85 | TOP1 (0.65) | TOP1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL5666583 | 0.85 | TOP1 (0.65) | TOP1CDK4CCND1CCNE2PRKACA | |
| SCHEMBL6736290 | 0.85 | TOP1 (0.57) | TOP1CDK4CCND1CCNE2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971717-B1 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | BRISTOL MYERS SQUIBB CO (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-0971717-A4 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | BRISTOL MYERS SQUIBB CO (US) | 2000-04-12 | — | — | EP | disclosed |
| EP-0971717-A1 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | Bristol-Myers Squibb Company (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998007433-A1 | CYTOTOXIC AMINO SUGAR AND RELATED SUGAR DERIVATIVES OF INDOLOPYRROLOCARBAZOLES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-02-26 | — | — | WO | disclosed |